p-trifluoromethoxy phenylhydrazine hydrochloride

p-trifluoromethoxy phenylhydrazine hydrochloride - Names and Identifiers

Name	4-(trifluoromethoxy)phenyl hydrazine hydrochloride
Synonyms	[4-(trifluoromethoxy)phenyl]hydrazine 4-trifluoromethylbenzene hydrazind HCl (4-TRIFLUOROMETHOXYPHENYL)-HYDRAZINE HCL TRIFLUOROMETHOXY)PHENYLHYDRAZINE HYDROCHLORIDE p-trifluoromethoxy phenylhydrazine hydrochloride 4-(Trifluoromethoxy)phenylhydrazine hydrochloride 4-(trifluoromethoxy)phenyl hydrazine hydrochloride 1-phenyl-1-(trifluoroMethoxy)hydrazine hydrochloride 1-[4-(Trifluoromethoxy)Phenyl]Hydrazine Hydrochloride HYDRAZINE, [4-(TRIFLUOROMETHOXY)PHENYL]-, HYDROCHLORIDE 2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide
CAS	133115-72-7
EINECS	236-341-9
InChI	InChI=1/C7H7F3N2O/c8-7(9,10)13-6-3-1-5(12-11)2-4-6/h1-4,12H,11H2

p-trifluoromethoxy phenylhydrazine hydrochloride - Physico-chemical Properties

Molecular Formula	C7H8ClF3N2O
Molar Mass	228.6
Density	1.408g/cm³
Melting Point	230°C(lit.)
Boling Point	228.9°C at 760 mmHg
Flash Point	92.2°C
Vapor Presure	0.0715mmHg at 25°C
Appearance	Yellow crystal
Color	White to pale brown
Storage Condition	under inert gas (nitrogen or Argon) at 2–8 °C
Refractive Index	1.526
MDL	MFCD00053033

p-trifluoromethoxy phenylhydrazine hydrochloride - Risk and Safety

Risk Codes	R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing.
WGK Germany	3
HS Code	29280000
Hazard Class	IRRITANT

p-trifluoromethoxy phenylhydrazine hydrochloride - Reference Information

application

4-trifluoromethoxyphenylhydrazine hydrochloride can be used as an organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and pharmaceutical and chemical production process.

Preparation

The suspension of 4-trifluoromethoxyaniline (20 mmol) in water (65 mL) and concentrated HCl (25 mL) was cooled to 0-5°C. Sodium nitrite (1.55g, 22 mmol) in water (15
mL) was added dropwise to the suspension of 4-trifluoromethoxyaniline (20 mmol) in water (65 mL) and concentrated HCl (25
mL). The reaction mixture was stirred at 0-5°C for 45 minutes. Add SnCl2 (40 mmol) concentrated HCl (10 mL)
solution to the reaction mixture. Add and let the temperature rise slowly until it reaches room temperature. Filter the suspension. Wash the remaining solids with saturated brine and ether. The solids were suspended in ether for several minutes under stirring. Filter solids. Dry solids.

Last Update：2024-04-09 15:16:37